منابع مشابه
Sox9 mediates Notch1-induced mesenchymal features in lung adenocarcinoma
Sox9 has gained increasing importance both functionally and as a prognostic factor in cancer. We demonstrate a functional role for Sox9 in inducing a mesenchymal phenotype in lung ADC. We show that Sox9 mRNA and protein are overexpressed in lung ADC, particularly those with KRAS mutations. Sox9 expression correlated with the Notch target gene Hes1, and numerous other Notch pathway components. W...
متن کاملUpregulation of SOX9 in lung adenocarcinoma and its involvement in the regulation of cell growth and tumorigenicity.
PURPOSE SOX9 is an important transcription factor required for development and has been implicated in several types of cancer. However, SOX9 has never been linked to lung cancer to date. Here, we show that SOX9 expression is upregulated in lung adenocarcinoma and show how it is associated with cancer cell growth. EXPERIMENTAL DESIGN Data mining with five microarray data sets containing 490 cl...
متن کاملUpregulation of FGF19 in lung adenocarcinoma and predicts poor prognosis
Fibroblast growth factor 19 (FGF19) belong to the FGF19 subfamily which is widely distributed in human tissues. FGF19 plays a crucial role in regulating various cellular processes. Recently, the researchers found that the aberrant expression of FGF19 in tumor development and progression. However, to our limited knowledge, whether FGF19 functions in lung adenocarcinoma remains unknown. In our re...
متن کاملGATA3-induced vWF upregulation in the lung adenocarcinoma vasculature
Lung adenocarcinoma (LAC) is the leading cause of cancer-related death worldwide. Aberrant expression of genes expressed preferentially in the lung tumor vasculature may yield clues for prognosis and treatment. Von Willebrand factor (vWF) is a large multifunctional glycoprotein with a well-known function in hemostasis. However, vWF has been reported to exert an anti-tumor effect, independent of...
متن کاملHuman Cancer Biology IL-10 Promotes Tumor Aggressiveness via Upregulation of CIP2A Transcription in Lung Adenocarcinoma
Purpose: Interleukin-10 (IL-10) determines virus persistent infection and promotes viral-associated tumor progression via tumor immune escape. However, the role of IL-10 in tumor progression and prognosis in lung adenocarcinoma remains controversial. Experimental Design: To investigate how IL-10 is regulated by HPV E6, IL-10 promoter was constructed to understand which transcriptional factor co...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Thorax
سال: 2010
ISSN: 0040-6376
DOI: 10.1136/thx.2010.153536